Lumbar spine surgery in patients with rheumatoid arthritis (RA): what affects the outcomes?
| Autor: | Kayo Suzuki, Yasuhito Yahara, Taketoshi Yasuda, Isao Matsushita, Yoshiharu Kawaguchi, Norikazu Hirano, Hiraku Motomura, Hiroto Makino, Masato Nakano, Kenta Watanabe, Shoji Seki, Tomoatsu Kimura |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Context (language use) Lumbar vertebrae Arthritis Rheumatoid 03 medical and health sciences Postoperative Complications Spinal Stenosis 0302 clinical medicine Lumbar medicine Humans Orthopedics and Sports Medicine Aged 030203 arthritis & rheumatology Lumbar Vertebrae business.industry Lumbar spinal stenosis Intervertebral disc Middle Aged Decompression Surgical medicine.disease Spondylolisthesis Surgery Spinal Fusion medicine.anatomical_structure Spinal decompression Rheumatoid arthritis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | The Spine Journal. 18:99-106 |
| ISSN: | 1529-9430 |
| Popis: | Background Context Although the cervical spine is only occasionally involved in rheumatoid arthritis (RA), involvement of the lumbar spine is even less common. A few reports on lumbar spinal stenosis in patients with RA have appeared. Although disc space narrowing occurs in aging, postoperative adjacent segment disease (ASD) in patients with RA has not been subject to much analysis. Purpose The objective of this study was to investigate differences in ASD and clinical outcomes between lumbar spinal decompression with and without fusion in patients with RA. Study Design/Setting This is a retrospective comparative study. Patient Sample A total of 52 patients with RA who underwent surgery for lumbar spinal disorders were included. Twenty-seven patients underwent decompression surgery with fusion and 25 underwent decompression surgery alone. Outcome Measures Intervertebral disc space narrowing and spondylolisthesis of the segment immediately cranial to the surgical site were measured using a three-dimensional volume rendering software. Pre- and postoperative evaluation of RA activity and Japanese Orthopaedic Association (JOA) scores were conducted. Materials and Methods All patients had preoperative and annual postoperative lumbar radiographs and were followed up for a mean of 5.1 years (range 3.5–10.9 years). Pre- and postoperative (2 years after surgery) JOA scores were recorded and any postoperative complications were investigated. Degrees of intervertebral disc narrowing and spondylolisthesis at the adjacent levels were evaluated on radiographs and were compared between the two groups. Analysis was performed to look for any correlation between ASD and RA disease activities. Results Postoperative JOA scores were significantly improved in both groups. The rate of revision surgery was significantly higher in the fusion group than that in the non-fusion group. The rate of ASD was significantly greater in the fusion group than that in the non-fusion group at the final follow-up examination. Both matrix metalloproteinase 3 (MMP-3) and the 28-joint disease activity score incorporating C-reactive protein levels (DAS28-CRP) were significantly associated with the incidence and severity of ASD. Conclusions Adjacent segment disease and the need for revision surgery were significantly higher in the fusion group than those in the non-fusion group. A preoperative high MMP-3 and DAS28-CRP are likely to be associated with postoperative ASD. |
| Databáze: | OpenAIRE |
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