Second donation of granulocyte-colony-stimulating factor-mobilized peripheral blood progenitor cells: risk factors associated with a low yield of CD34+ cells
| Autor: | Gerhard Ehninger, Martin Bornhäuser, Linda Lerche, Kristin Zimmer, Kristina Hölig, Uwe Platzbecker, Claudia Rutt |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Allogeneic transplantation Immunology CD34 Antigens CD34 Blood Donors Lenograstim Andrology Risk Factors Granulocyte Colony-Stimulating Factor Humans Immunology and Allergy Medicine Risk factor Progenitor cell Aged Mobilization business.industry Hematology Middle Aged Hematopoietic Stem Cells Hematopoietic Stem Cell Mobilization Recombinant Proteins Blood Cell Count Granulocyte colony-stimulating factor Multivariate Analysis Female business Body mass index |
| Zdroj: | Transfusion. 45:11-15 |
| ISSN: | 1537-2995 0041-1132 |
| Popis: | BACKGROUND: There are still limited data on the efficacy and safety of repeated donations of granulocyte–colony-stimulating factor (G–CSF)-mobilized peripheral blood progenitor cells (PBPCs) for allogeneic transplantation. STUDY DESIGN AND METHODS: Sixty-seven healthy donors undergoing two consecutive mobilizations of PBPCs within a median interval of 5 months (range, 0.1-47 months) were investigated. For both first mobilization (FM) and second mobilization (SM), G–CSF (lenograstim) at 7.5 µg per kg per day was administered. RESULTS: The nonhematologic side effects were comparable between both mobilizations. A significantly lower yield of CD34+ cells × 106 per kg of donor weight was obtained on Day 5 of SM in female (n = 31; FM, 5.0; SM, 3.23; p = 0.008) but not in male (n = 36; FM, 5.96; SM, 5.36; p = 0.24) donors. Multivariate analysis identified a lower CD34+ blood concentration on Day 5 of FM (p |
| Databáze: | OpenAIRE |
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