Marginalized Two-Part Joint Modeling of Longitudinal Semi-Continuous Responses and Survival Data: With Application to Medical Costs
| Autor: | Anoshirvan Kazemnejad, Farid Zayeri, Sayed Jamal Mirkamali, Mohadeseh Shojaei Shahrokhabadi, (Din) Ding-Geng Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Series (mathematics)
Proportional hazards model Computer science General Mathematics right-skewed proportional hazards model zero-inflated marginalized two-part joint model Set (abstract data type) semi-continuous Standard error Statistics Linear regression Covariate Computer Science (miscellaneous) QA1-939 medical costs data conventional two-part joint model Engineering (miscellaneous) Medical costs Joint (geology) Mathematics |
| Zdroj: | Mathematics Volume 9 Issue 20 Mathematics, Vol 9, Iss 2603, p 2603 (2021) |
| ISSN: | 2227-7390 |
| DOI: | 10.3390/math9202603 |
| Popis: | Non-negative continuous outcomes with a substantial number of zero values and incomplete longitudinal follow-up are quite common in medical costs data. It is thus critical to incorporate the potential dependence of survival status and longitudinal medical costs in joint modeling, where censorship is death-related. Despite the wide use of conventional two-part joint models (CTJMs) to capture zero-inflation, they are limited to conditional interpretations of the regression coefficients in the model’s continuous part. In this paper, we propose a marginalized two-part joint model (MTJM) to jointly analyze semi-continuous longitudinal costs data and survival data. We compare it to the conventional two-part joint model (CTJM) for handling marginal inferences about covariate effects on average costs. We conducted a series of simulation studies to evaluate the superior performance of the proposed MTJM over the CTJM. To illustrate the applicability of the MTJM, we applied the model to a set of real electronic health record (EHR) data recently collected in Iran. We found that the MTJM yielded a smaller standard error, root-mean-square error of estimates, and AIC value, with unbiased parameter estimates. With this MTJM, we identified a significant positive correlation between costs and survival, which was consistent with the simulation results. |
| Databáze: | OpenAIRE |
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