A New and Improved Method for Deglycosidation of Glycopeptide Antibiotics Exemplified with Vancomycin, Ristocetin, and Ramoplanin

Autor:	Brendan M. Crowley, Casey Cameron Mccomas, Jason A. Moss, Dale L. Boger, Wanlong Jiang, Datong Tang, Jutta Wanner
Rok vydání:	2003
Předmět:	General method Stereochemistry Pyridines medicine.drug_class Clinical Biochemistry Antibiotics Pharmaceutical Science Improved method Biochemistry Peptides Cyclic Hydrofluoric Acid chemistry.chemical_compound Vancomycin Depsipeptides Drug Discovery medicine Ristocetin Molecular Biology Chromatography High Pressure Liquid Depsipeptide Chemistry Organic Chemistry General Medicine Ramoplanin Combinatorial chemistry Glycopeptide Anti-Bacterial Agents Solvents Molecular Medicine Indicators and Reagents medicine.drug
Zdroj:	ChemInform. 34
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200328229
Popis:	A general method for the deglycosidation of glycopeptide antibiotics has been developed. Treatment of vancomycin, ristocetin, and ramoplanin with anhydrous HF results in efficient cleavage of the sugars to provide the corresponding aglycons in high yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41622cee94c2fc83f919f3f7890ba2c6 https://doi.org/10.1002/chin.200328229 Zobrazit plný text záznamu Plný text