Effect of Mindfulness-Based stress reduction in rheumatoid arthritis patients
| Autor: | Adele M. K. Gilpin, Trish Magyari, Mona Baumgarten, Elizabeth K. Pradhan, Marc C. Hochberg, Barry S. Handwerger, Brian Berman, Patricia Langenberg |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Mindfulness Immunology Arthritis law.invention Arthritis Rheumatoid Mindfulness-based stress reduction Rheumatology Randomized controlled trial law Surveys and Questionnaires medicine Humans Immunology and Allergy Pharmacology (medical) Disease management (health) Depression (differential diagnoses) Depression business.industry Repeated measures design medicine.disease Meditation Treatment Outcome Rheumatoid arthritis Physical therapy Female business Stress Psychological |
| Zdroj: | Arthritis & Rheumatism. 57:1134-1142 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.23010 |
| Popis: | Objective To assess the effect of a meditation training program, Mindfulness-Based Stress Reduction (MBSR), on depressive symptoms, psychological status, and disease activity in patients with rheumatoid arthritis (RA) through a randomized, waitlist-controlled pilot study. Methods Participants were randomized to either an MBSR group, where they attended an 8-week course and 4-month maintenance program, or to a waitlist control group, where they attended all assessment visits and received MBSR free of charge after study end. Participants received usual care from their rheumatologists throughout the trial. Self-report questionnaires were used to evaluate depressive symptoms, psychological distress, well-being, and mindfulness. Evaluation of RA disease activity (by Disease Activity Score in 28 joints) included examination by a physician masked to treatment status. Adjusted means and mean changes in outcomes were estimated in mixed model repeated measures analyses. Results Sixty-three participants were randomized: 31 to MBSR and 32 to control. At 2 months, there were no statistically significant differences between groups in any outcomes. At 6 months, there was significant improvement in psychological distress and well-being (P = 0.04 and P = 0.03, respectively), and marginally significant improvement in depressive symptoms and mindfulness (P = 0.08 and P = 0.09, respectively). There was a 35% reduction in psychological distress among those treated. The intervention had no impact on RA disease activity. Conclusion An 8-week MBSR class was not associated with change in depressive symptoms or other outcomes at 2-month followup. Significant improvements in psychological distress and well-being were observed following MBSR plus a 4-month program of continued reinforcement. Mindfulness meditation may complement medical disease management by improving psychological distress and strengthening well-being in patients with RA. |
| Databáze: | OpenAIRE |
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