Testicular toxicity induced by single dosing of di- and mono-(2-ethylhexyl) phthalate in the rat
| Autor: | M.G. Bogaert, O. Teirlynck, H. Roels, J.M. Kaufman |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Metabolite Phthalic Acids Testicle Toxicology chemistry.chemical_compound Oral administration Plasticizers Internal medicine Diethylhexyl Phthalate Testis medicine Animals Dosing Testicular atrophy Chemistry Phthalate General Medicine medicine.disease Rats Zinc Endocrinology medicine.anatomical_structure Toxicity Testicular toxicity Follicle Stimulating Hormone |
| Zdroj: | Toxicology letters. 40(1) |
| ISSN: | 0378-4274 |
| Popis: | The testicular toxicity of di-(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, and of its major metabolite, mono-(2-ethylhexyl) phthalate (MEHP), was assessed after a single dose in rats. Treatment with a single dose of 2.8 g/kg DEHP or 0.8 g/kg MEHP was sufficient to induce testicular atrophy as observed 7 days after dosing. Such a treatment had no effect on plasma FSH levels, and had varying effects on testicular zinc concentrations. After a single dose of 0.8 g/kg MEHP the testicular toxicity was age-dependent, in that only prepubertal rats were susceptible. |
| Databáze: | OpenAIRE |
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