Sedative effects of intramuscular alfaxalone administered to cats
| Autor: | Tomohito Ishizuka, Jun Tamura, Kazuto Yamashita, Kenjiro Miyoshi, Takaharu Itami, Tadashi Sano, Kodai Kawase, Kirby Pasloske, Norihiko Oyama, Sho Fukui |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Sedative effect Lateral recumbency Scoring system Sedation Blood Pressure Injections Intramuscular Pregnanediones Body Temperature Heart Rate Medicine Animals Hypnotics and Sedatives feline CATS General Veterinary Full Paper alfaxalone business.industry Alfaxalone Early recovery sedation intramuscular administration Anesthesia Injections Intravenous Sedative Effects Cats Female Surgery medicine.symptom Deep Sedation business medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 0916-7250 |
| Popis: | The sedative effects of intramuscular (IM) alfaxalone in 2-hydroxypropyl-beta-cyclodextrin (alfaxalone-HPCD) were evaluated in cats. The cats were treated with alfaxalone-HPCD in five occasions with a minimum 14-day interval between treatments: an IM injection of 1.0 mg/kg (IM1), 2.5 mg/kg (IM2.5), 5 mg/kg (IM5) or 10 mg/kg (IM10), or an intravenous injection of 5 mg/kg (IV5). The sedative effects were evaluated subjectively using a composite measurement scoring system (a maximum score of 16). Cardio-respiratory variables were measured non-invasively. The median sedation scores peaked at 10 min (score 9), 15 min (score 14), 10 min (score 16), 10 to 20 min (score 16) and 2 to 5 min (score 16) after the IM1, IM2.5, IM5, IM10 and IV5 treatments, respectively. The IM5 treatment produced longer lasting sedation, compared to the IV5 treatment. Durations of maintenance of lateral recumbency after the IM10 treatment (115 ± 22 min) were longer than those after the IM2.5 (40 ± 15 min), IM5 (76 ± 21 min) and IV5 treatments (50 ± 5 min). Cardio-respiratory variables remained within clinically acceptable ranges, except for each one cat that showed hypotension ( |
| Databáze: | OpenAIRE |
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