Intermittent detection of hepatitis C virus (HCV) in semen from men with human immunodeficiency virus type 1 (HIV-1) and HCV
| Autor: | Alain Berrebi, Jacques Izopet, Laetitia Berges, Jacqueline Puel, Myriam Daudin, Laurence Righi, Patrice Massip, Laurence Thauvin, Louis Bujan, Christophe Pasquier |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Reproductive Techniques Assisted Hepatitis C virus HIV Infections Semen Hepacivirus medicine.disease_cause Virus Flaviviridae Virology medicine Humans Viral shedding biology virus diseases Hepatitis C Viral Load medicine.disease biology.organism_classification digestive system diseases Virus Shedding Infectious Diseases Immunology Lentivirus HIV-1 RNA Viral Viral load |
| Zdroj: | Journal of Medical Virology. 69:344-349 |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.10295 |
| Popis: | HCV is usually transmitted via the blood, but HCV RNA has been detected recently in seminal fluid. This study was done to study HCV seminal shedding and factors that could influence the presence of HCV in the seminal fluid of men coinfected with HCV and HIV-1. HCV and HIV-1 genomes were assayed in multiple paired blood and semen samples obtained from 35 men enrolled in an assisted medical procreation protocol. HCV RNA was found intermittently in semen samples from 9 patients (25.7%). Samples from 9 men with HCV RNA in their semen and 26 men without were compared to further analyze these parameters. No correlation was found between HCV RNA in the seminal fluid and age, HCV virus load, the duration of HIV-1 infection, HIV treatment, the CD4(+) cell count, HIV-1 virus load or HIV-1 detection in the semen. The intermittent detection of HCV RNA in semen samples support the systematic search for HCV RNA in semen and the use of processed spermatozoa in assisted medical procreation of infertile HCV serodiscordant couples. |
| Databáze: | OpenAIRE |
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