Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia

Autor: G. van Staveren, Katja Taxis, E A van der Zee, M. J. G. van Heuvelen, Willem J R Bossers, L. M. J. Sanders, Christiaan G. Blankevoort, Hans C. Klein, Tibor Hortobágyi, Erik J. A. Scherder, Froukje Boersma
Přispěvatelé: SMART Movements (SMART), Methods in Medicines evaluation & Outcomes research (M2O), PharmacoTherapy, -Epidemiology and -Economics, Van der Zee lab, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Clinical Neuropsychology, IBBA
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Inappropriate prescribing
Medication
Cognition
0302 clinical medicine
Activities of Daily Living
Drug Burden Index
Hypnotics and Sedatives
Medicine
Pharmacology (medical)
030212 general & internal medicine
Prospective cohort study
INDEX
media_common
Aged
80 and over
OUTCOMES
General Medicine
DWELLING OLDER-PEOPLE
Female
POLYPHARMACY
AUSTRALIAN MEN
Drug
medicine.medical_specialty
Pharmacoepidemiology and Prescription
medicine.drug_class
Nursing home facilities
media_common.quotation_subject
ANTICHOLINERGIC BURDEN
Sample (statistics)
03 medical and health sciences
SDG 3 - Good Health and Well-being
Anticholinergic
Humans
Dementia
Aged
Pharmacology
Polypharmacy
Inpatients
business.industry
INAPPROPRIATE MEDICATION USE
RESIDENTIAL AGED CARE
ADULTS
medicine.disease
Nursing Homes
Cross-Sectional Studies
PROSPECTIVE COHORT
Sedative
Physical therapy
Cholinesterase Inhibitors
business
030217 neurology & neurosurgery
Zdroj: Sanders, L M J, Hortobágyi, T, van Staveren, G, Taxis, K, Boersma, F, Klein, H C, Bossers, W J R, Blankevoort, C G, Scherder, E J A, Van der Zee, E A & van Heuvelen, M J G 2017, ' Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia ', European Journal of Clinical Pharmacology, vol. 73, no. 12, pp. 1633-1642 . https://doi.org/10.1007/s00228-017-2319-y
European Journal of Clinical Pharmacology, 73(12), 1633-1642. Springer Verlag
European Journal of Clinical Pharmacology
ISSN: 0031-6970
Popis: Purpose The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical functions in a sample of patients with dementia. Methods Using performance-based tests, we measured physical and cognitive functions in 140 nursing home patients aged over 70 with all-cause dementia. We also determined anticholinergic DBI (AChDBI) and sedative DBI (SDBI) separately and in combination as total drug burden (TDB). Results Nearly one half of patients (48%) used at least one DBI-contributing drug. In 33% of the patients, drug burden was moderate (0 0.05). Conclusions A lack of association between drug burden and physical or cognitive function in this sample of patients with dementia could imply that drug prescribing is more optimal for patients with dementia compared with healthy older populations. However, such an interpretation of the data warrants scrutiny as several dementia-related factors may confound the results of the study. Electronic supplementary material The online version of this article (10.1007/s00228-017-2319-y) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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