The development and characterization of a novel yet simple 3D printed tool to facilitate phantom imaging of photoacoustic contrast agents
| Autor: | Jeanne E. Lemaster, Jesse V. Jokerst, Junxin Wang, Santiago J. Arconada-Alvarez |
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| Rok vydání: | 2017 |
| Předmět: |
Absorption (acoustics)
Materials science Phantom media_common.quotation_subject lcsh:QC221-246 3D printing 02 engineering and technology 01 natural sciences Signal Imaging phantom 010309 optics 0103 physical sciences lcsh:QC350-467 Contrast (vision) Radiology Nuclear Medicine and imaging ComputingMethodologies_COMPUTERGRAPHICS media_common Focal point business.industry Optoacoustic imaging 021001 nanoscience & nanotechnology lcsh:QC1-999 Atomic and Molecular Physics and Optics Characterization (materials science) Transducer lcsh:Acoustics. Sound Photoacoustic imaging 0210 nano-technology business lcsh:Physics lcsh:Optics. Light Research Article Biomedical engineering |
| Zdroj: | Photoacoustics, Vol 5, Iss C, Pp 17-24 (2017) Photoacoustics |
| ISSN: | 2213-5979 |
| DOI: | 10.1016/j.pacs.2017.02.001 |
| Popis: | Graphical abstract Highlights • A 3D printed phantom was designed and fabricated to validate photoacoustic contrast agents. • Methylene blue was used as a contrast agent to validate the performance metrics of the phantom under the PA imaging system. • The signal inherent to different types of tubing was quantified. • India Ink and lipids were added to the media to simulate tissue absorption. • The signal at multiple distances from the laser focal point was measured. We report a new approach to preparing phantoms using 3D printing. This device supports plastic tubing containing the contrast agent and is immersed in a solution with absorption or scattering properties that mimic tissue. Up to 12 tubing samples could be placed in the device with sample-to-sample spacing as low as 0.3 mm and at a constant distance from the transducer (±0.16 mm), which is critical in validating photoacoustic contrast agents. We also studied different types of tubing and found that tubing with a larger outside diameter has more inherent signal. Both 40% India Ink and lipids in the immersion media modulated the signal. Finally, we created a depth phantom and found that signal decayed following a linear relationship (R2 = 0.997) with respect to distance from the focal point. We include computer-assisted drafting code the community can use to print this phantom or customized versions of this phantom. |
| Databáze: | OpenAIRE |
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