Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case-Control Study
| Autor: | Connor Graham, Catherine Metayer, Libby M. Morimoto, Joseph L. Wiemels, Arfan Siddique, Mengyang Di, Rozalyn L. Rodwin, Nina S. Kadan-Lottick, Xiaomei Ma, Rong Wang |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Adolescent Lymphoma Epidemiology Reproductive health and childbirth Medical and Health Sciences Article Young Adult Rare Diseases Clinical Research Ethnicity Humans Child Preschool Cancer Prevention Racial Groups Infant Newborn Infant Hispanic or Latino Hematology Newborn Hodgkin Disease United States Good Health and Well Being Oncology Child Preschool Case-Control Studies Female |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol 31, iss 9 Cancer Epidemiol Biomarkers Prev |
| Popis: | Background: Hispanic ethnicity differences in the risk of early-onset Hodgkin lymphoma diagnosed at Methods: This study included 1,651 non-Hispanic White and 1,168 Hispanic cases with Hodgkin lymphoma endorsing a range of races diagnosed at the age of 0 to 37 years during 1988–2015 and 140,950 controls without cancer matched on race/ethnicity and year of birth from the California Linkage Study of Early-Onset Cancers. OR and 95% confidence intervals (CI) were estimated from multivariable logistic regression models. Results: Having a foreign-born mother versus a United States–born mother (i.e., the reference group) was associated with an increased risk of early-onset Hodgkin lymphoma among non-Hispanic Whites (OR = 1.52; 95% CI, 1.31–1.76; P < 0.01) and a decreased risk among Hispanics (OR = 0.78; 95% CI, 0.69–0.88; P < 0.01). Among both race groups, risk of early-onset Hodgkin lymphoma increased with birthweight and maternal age (all Ptrends < 0.01). Among non-Hispanic Whites, each 5-year increase in maternal age (OR = 1.11; 95% CI, 1.04–1.18; Ptrend < 0.01) and paternal age (OR = 1.07; 95% CI, 1.02–1.13; Ptrend < 0.01) was associated with increased risk of early-onset Hodgkin lymphoma. Compared with female Hispanics, male Hispanics had an increased risk of early-onset Hodgkin lymphoma (OR = 1.26; 95% CI, 1.12–1.42; P < 0.01). Conclusions: Maternal birthplace may play a role in risk of early-onset Hodgkin lymphoma that differs by ethnicity. Impact: The ethnic differences observed between certain birth characteristics, maternal birthplace, and early-onset Hodgkin lymphoma raise questions about the underlying biological, generational, lifestyle, residential, and genetic contributions to the disease. |
| Databáze: | OpenAIRE |
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