Vγ4 γδ T Cells Provide an Early Source of IL-17A and Accelerate Skin Graft Rejection
| Autor: | Guangping Liang, Rongshuai Yan, Xiaorong Zhang, Gaoxing Luo, Meixi Liu, Weifeng He, Zhenggen Huang, Yashu Li, Chibing Huang, Xiaohong Hu, Jian Chen, Baoyi Liu, Jun Wu, Yang Bai |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
Male Receptors CCR6 0301 basic medicine Chemokine T cell Dermatology C-C chemokine receptor type 6 Biology Ligands Interleukin-23 Biochemistry Mice 03 medical and health sciences 0302 clinical medicine Antigen Dermis T-Lymphocyte Subsets medicine Animals Molecular Biology Skin Chemokine CCL20 integumentary system Interleukin-17 Receptors Antigen T-Cell gamma-delta Skin Transplantation Cell Biology Dendritic cell Mice Inbred C57BL CCL20 Transplantation surgical procedures operative 030104 developmental biology medicine.anatomical_structure Immunology biology.protein Female Lymph Nodes Chemokines 030215 immunology |
| Zdroj: | Journal of Investigative Dermatology. 137:2513-2522 |
| ISSN: | 0022-202X |
| DOI: | 10.1016/j.jid.2017.03.043 |
| Popis: | Activated γδ T cells have been shown to accelerate allograft rejection. However, the precise role of skin-resident γδ T cells and their subsets-Vγ5 (epidermis), Vγ1, and Vγ4 (dermis)-in skin graft rejection have not been identified. Here, using a male to female skin transplantation model, we demonstrated that Vγ4 T cells, rather than Vγ1 or Vγ5 T cells, accelerated skin graft rejection and that IL-17A was essential for Vγ4 T-cell-mediated skin graft rejection. Moreover, we found that Vγ4 T cells were required for early IL-17A production in the transplanted area, both in skin grafts and in the host epidermis around grafts. Additionally, the chemokine (C-C motif) ligand 20-chemokine receptor 6 pathway was essential for recruitment of Vγ4 T cells to the transplantation area, whereas both IL-1β and IL-23 induced IL-17A production from infiltrating cells. Lastly, Vγ4 T-cell-derived IL-17A promoted the accumulation of mature dendritic cells in draining lymph nodes to subsequently regulate αβ T-cell function after skin graft transplantation. Taken together, our data reveal that Vγ4 T cells accelerate skin graft rejection by providing an early source of IL-17A. |
| Databáze: | OpenAIRE |
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