Collection devices for obtaining cervical cytology samples
| Autor: | Gerry G Jarvis, Pierre Pl Martin‐Hirsch, Richard J. Lilford, Henry C Kitchener |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Colposcopy
Vaginal Smears medicine.medical_specialty Clinical Trials as Topic medicine.diagnostic_test Obstetrics Dyskaryosis business.industry Uterine Cervical Neoplasms Cervical cytology Odds ratio medicine.disease Confidence interval medicine Humans Pharmacology (medical) Sampling (medicine) Observational study Female business After treatment |
| Zdroj: | The Cochrane Library |
| ISSN: | 1469-493X |
| Popis: | Background Few randomised controlled trials have sufficient power to show clear advantages of different designs of cervical smear collection devices. We studies whether the design of the cervical smear collection device affects rates of inadequate smears and detection of disease and whether the presence of endocervical cells in the smear affects detection of disease. Objectives The false-negative rate of cervical smears varies between 1.5% and 55%. This variation may be partly due to differences in sampling device and technique. The objective of this review was to assess different cervical sampling devices for collecting endocervical cells, which are thought to be a surrogate for detection of abnormal cells and adequate smear rates. Search strategy We searched the Cochrane Gynaecological Cancer Group trials register and MEDLINE up to July 1997. We also handsearched 16 journals. Selection criteria Randomised and quasi-randomised trials and non-randomised comparative studies comparing cervical smear collection devices in women attending for primary screening, colposcopy following an abnormal smear or colposcopy after treatment. Data collection and analysis Two reviewers independently abstracted data. Study quality was assessed. Main results Thirty-four trials and six observational comparative studies were included. The Ayre spatula was shown to be less effective compared with extended tip spatulas for collecting endocervical cells in eight trials (odds ratio 2.25, 95% confidence interval 2.06 to 2.44). Use of a spatula with the cytobrush was more effective than spatula alone at collecting endocervical cells (odds ratio 3.33, 95% 3.05 to 3.63) and the same effect was present for adequate smear rates (odds ratio 1.51 95% 1.19-1.92). Extended tip spatulas were also superior for the detection of dyskaryosis in seven trials (odds ratio 1.21, 95% confidence interval 1.10 to 1.33). Based on data from two trials and three observational studies, smears that contained endocervical cells were more likely to detect dyskaryosis, particularly in severe disease. The proportion of smears with endocervical cells present increased with increasing severity of the disease. Reviewer's conclusions Extended tip spatulas of various designs appear to be better for collecting endocervical cells than the commonly used Ayre spatula. The most effective combination appears to be the cytobrush with an extended tip spatula. The rate of detection of endocervical cells appears to be a valid and convenient surrogate for the ability to detect dyskaryosis and for adequate smear rates. The ability of the extended tip spatula with the cytobrush compared with the extended tip spatula alone to detect disease, needs to be evaluated in a trial. |
| Databáze: | OpenAIRE |
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