The effects of hypothyroidism and hyperthyroidism on placental Hofbauer cells of pregnant rats
| Autor: | Zahide Çavdar, Cemre Ural, Gokcen Bilici, Uygar Sacik, Guven Erbil |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Vascular Endothelial Growth Factor A endocrine system medicine.medical_specialty Histology endocrine system diseases Placenta Intrauterine growth restriction Hyperthyroidism 03 medical and health sciences 0302 clinical medicine Hypothyroidism Pregnancy Internal medicine medicine Animals Fetus Fetal viability 030102 biochemistry & molecular biology business.industry Thyroid General Medicine medicine.disease Placentation Rats Medical Laboratory Technology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis embryonic structures Hofbauer cell Female Propylthiouracil Decidua Basalis business medicine.drug |
| Popis: | We investigated the effects of maternal thyroid disorders on Hofbauer cells of both the placenta and the fetus in pregnant rats. We divided 21 rats into three groups: control group, induced hypothyroidism (hypo) group and induced hyperthyroidism (hyper) group. Hypothyroidism was induced using propylthiouracil and hyperthyroidism was induced using L-thyroxine. We measured maternal weight, maternal free thyroxine, fetal weight, fetal viability and placental morphology. At the end of the experiment, fetuses of the hypo and hyper groups were less developed than those of the control group. In the hypo and hyper groups, the thickness of the labyrinth zone was decreased, but thickness of the basal zone and decidua basalis was increased. The number of Hofbauer cells was increased in both the hypo and hyper groups. Vascular endothelial growth factor expression was increased in both the hypo and hyper groups compared to controls. Our findings indicate that maternal thyroid disorders exert a negative effect on fetal growth and placental development. |
| Databáze: | OpenAIRE |
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