A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts
| Autor: | Junetha Syed, Ganesh N. Pandian, Gengo Kashiwazaki, Kaori Hashiya, Anandhakumar Chandran, Toshikazu Bando, Junichi Taniguchi, Shinsuke Sato, Hiroshi Sugiyama |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Transcriptional Activation
Response element Biochemistry Retina transcription profiling Cell Line Epigenesis Genetic Histones Small Molecule Libraries Retinal Diseases Transcription (biology) Gene expression Histone methylation Humans Pyrroles Epigenetics Molecular Biology DNA recognition biology Gene Expression Profiling Organic Chemistry histone acetylation Imidazoles Promoter Acetylation Fibroblasts Histone Cancer research biology.protein gene expression Molecular Medicine artificial transcription activators Epigenetic therapy |
| Zdroj: | Chembiochem : a European journal of chemical biology. 16(10) |
| ISSN: | 1439-7633 |
| Popis: | Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue-restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small-molecule compound—termed “SAHA–PIP X”—from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal-tissue-related genes in human dermal fibroblasts (HDFs). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text