Prevalence and concordance of high-risk papillomavirus infection in male sexual partners of women diagnosed with high grade cervical lesions

Autor: Máximo Castro, Elena López Diez, Angel de la Orden, L. Tortolero, Ruben Montero, Sheila Almuster, Sonia Pérez, Amparo Iñarrea, Moises Rodríguez, Antonio Ojea
Rok vydání: 2017
Předmět:
Adult
Male
Microbiology (medical)
medicine.medical_specialty
Disease reservoir
Genotyping Techniques
Cross-sectional study
Concordance
Uterine Cervical Neoplasms
Genitalia
Male
Cervical intraepithelial neoplasia
03 medical and health sciences
0302 clinical medicine
Epidemiology
Genotype
Prevalence
medicine
Humans
030212 general & internal medicine
Papillomaviridae
Human Papillomavirus DNA Test
Mass screening
Disease Reservoirs
Gynecology
Human papillomavirus 16
biology
Obstetrics
business.industry
Papillomavirus Infections
HPV infection
virus diseases
Middle Aged
Uterine Cervical Dysplasia
medicine.disease
biology.organism_classification
female genital diseases and pregnancy complications
Cross-Sectional Studies
Sexual Partners
Spain
030220 oncology & carcinogenesis
Carrier State
DNA
Viral
Female
business
Zdroj: Enfermedades Infecciosas y Microbiología Clínica. 35:273-277
ISSN: 0213-005X
DOI: 10.1016/j.eimc.2016.02.014
Popis: Background Little is known about the characteristics of high-risk papillomavirus (HR-HPV) infection in men. The aims of this cross-sectional study were: (a) to investigate HR-HPV prevalence and genotype distribution in men, sexual partners of women presenting with high-grade cervical intraepithelial neoplasia (HG-CIN), according to epidemiological characteristics, and (b) to assess type-specific concordance between partners. Methods A total of 125 men were recruited within the first 6 months after HG-CIN diagnosis of their partner. Samples from the coronal sulcus, glans penis shaft, and scrotum were tested with linear array HPV genotyping assay (Roche Diagnostics, Mannheim, Germany). Type-specific concordance within 120 couples was studied. Epidemiological factors were evaluated by multivariate logistic regression analysis. SPSS 19 (IBM, Chicago, USA). Results The prevalence of HR-HPV infection in males was 50.4% (63/125). HPV16/53/52/51/66/31 were the most frequent genotypes (24/10.4/9.6/8.8/8/7.2%, respectively). Current smoking was associated with an increased risk for HR-HPV infection in men (38.2% (21/55) vs 60% (42/70), OR 2.4, p = 0.025). Among 60 infected couples, 62% shared at least one genotype: 41.7% couples were concordantly HPV16 positive and 18.3% were HPV16 negative (kappa value: 0.21). The proportion of women with the same genotype as their male partner was higher than the proportion of men sharing the same genotype as their female partner: 58.7% (37/63) vs 30.8% (37/120), p Conclusions Sexual partners of women with HG-CIN are a significant reservoir and vector of HPV infection, a fact that could contribute to making viral clearance more difficult to achieve in their partners after treatment of their HG-CIN lesions.
Databáze: OpenAIRE
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