Myocardial collagen deposition and inflammatory cell infiltration in cats with pre-clinical hypertrophic cardiomyopathy
| Autor: | Fiona Kumari Campbell, Ian A. Shiels, Kuan Hua Khor, Helen Owen, Paul C. Mills |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pathology Heart Ventricles Diastole Inflammation Cat Diseases Muscle hypertrophy Internal medicine Animals Medicine cardiovascular diseases CATS General Veterinary business.industry Hypertrophic cardiomyopathy Cardiomyopathy Hypertrophic medicine.disease Inflammatory cell infiltration Echocardiography Cats cardiovascular system Etiology Cardiology Female Animal Science and Zoology Myocardial fibrosis Collagen medicine.symptom business |
| Zdroj: | The Veterinary Journal. 203:161-168 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2014.11.018 |
| Popis: | The histological features of feline hypertrophic cardiomyopathy (HCM) have been well documented, but there are no reports describing the histological features in mild pre-clinical disease, since cats are rarely screened for the disease in the early stages before clinical signs are apparent. Histological changes at the early stage of the disease in pre-clinical cats could contribute to an improved understanding of disease aetiology or progression. The aim of this study was to evaluate the histological features of HCM in the left ventricular (LV) myocardium of cats diagnosed with pre-clinical HCM. Clinically healthy cats with normal (n = 11) and pre-clinical HCM (n = 6) were identified on the basis of echocardiography; LV free wall dimensions (LVFWd) and/or interventricular septal wall (IVSd) dimensions during diastole of 6–7 mm were defined as HCM, while equivalent dimensions |
| Databáze: | OpenAIRE |
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