Disseminated Miliary Tuberculosis of the Skin in Patients with AIDS: Report of Four Cases
| Autor: | M. J. Saldana, George L. Daikos, T. Cleary, N. Miller, Raj B. Uttamchandani, C. Tuda, Margaret A. Fischl |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Microbiology (medical) Pathology medicine.medical_specialty Miliary tuberculosis Tuberculosis Opportunistic infection Mycobacterium tuberculosis Fatal Outcome Acquired immunodeficiency syndrome (AIDS) Tuberculosis Multidrug-Resistant medicine Humans Sida Tuberculosis Cutaneous Acquired Immunodeficiency Syndrome biology Tuberculosis Miliary business.industry Isoniazid medicine.disease biology.organism_classification Infectious Diseases HIV-1 Viral disease business medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 27:205-208 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/514608 |
| Popis: | We present clinical, bacteriologic, and pathological findings for four patients with AIDS and cutaneous miliary tuberculosis. All patients had generalized tuberculosis with hematogenous dissemination to multiple organs including the skin. Microscopic examination of the skin lesions revealed ill-formed or no granulomata, extensive necrosis, and numerous acid-fast bacilli. Mycobacterium tuberculosis was detected in the skin lesions by cultures for three patients and by polymerase chain reaction for one. Three of the isolates were resistant to at least isoniazid and rifampin, and one was susceptible to these drugs. The outcome was rapidly fatal for the three patients with multidrug-resistant tuberculosis. This report draws attention to the reappearance of a once-rare manifestation of disseminated tuberculosis which, in the setting of advanced human immunodeficiency virus disease, may offer the first indication of infection with multidrug-resistant M. tuberculosis and a poor prognosis. |
| Databáze: | OpenAIRE |
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