Conversion pattern and predictive factor of mild cognitive impairment in elderly Koreans
| Autor: | Jong Hoon Kim, Jihyun Song, Sung Mi Shim, Jae Pil Jeon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Gerontology Aging medicine.medical_specialty Health (social science) Clinical Dementia Rating Physical examination Neuropsychological Tests Audiology Logistic regression behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Memory Predictive Value of Tests Risk Factors Weight loss Republic of Korea Weight Loss mental disorders medicine Humans Dementia Cognitive Dysfunction 030212 general & internal medicine Cognitive decline Aged Aged 80 and over medicine.diagnostic_test Neuropsychology Middle Aged medicine.disease Predictive value of tests Disease Progression Female Geriatrics and Gerontology medicine.symptom Psychology 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Archives of Gerontology and Geriatrics. 64:146-150 |
| ISSN: | 0167-4943 |
| DOI: | 10.1016/j.archger.2016.02.007 |
| Popis: | Objective We aimed to understand conversion characteristics of mild cognitive impairment (MCI) in elderly Koreans. Methods We analyzed clinical data of 760 individuals who participated in a two-year follow-up study. Neuropsychological assessments and clinical examination were conducted in the follow-ups. Logistic regression model was used to estimate predictive risk factors of MCI conversion. Result The participants at baseline ( n = 760) represented 462 cognitively normal individuals (60.8%), 286 individuals with MCI (37.6%), and 12 individuals with dementia (1.6%). Among the cognitively normal individuals ( n = 462), 108 (23.4%) progressed to MCI during the two-year follow-up period, including 92 with amnestic mild cognitive impairment (aMCI; 19.9%) and 16 with non-amnestic mild cognitive impairment (non-aMCI; 3.5%). Interestingly, 3.7% of participants with aMCI converted to non-aMCI, while 45.5% of participants with non-aMCI converted to aMCI. Moreover, a higher proportion of non-aMCI (27.3%) reverted to a cognitively normal state, compared to aMCI participants (18.6%), indicating that non-amnestic cognitive impairment is more unstable than amnestic cognitive impairment, and probably converges toward aMCI. Additionally, we found that weight loss was associated with incident MCI and future MCI. Weight loss was negatively correlated with Clinical Dementia Rating ( p = 0.005), and significantly associated with a higher risk of MCI conversion from a cognitively normal state (OR = 1.10, 95% CI: 1.00–1.21, p = 0.042). Conclusion This study supports that non-amnestic MCI is prone to converge toward amnestic MCI, and the elderly people with weight loss are at risk for developing cognitive decline. |
| Databáze: | OpenAIRE |
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