Evaluation of strontium Sr 90 for the treatment of superficial squamous cell carcinoma of the nasal planum in cats: 49 cases (1990–2006)
| Autor: | Genevieve M. Hammond, Alain P Theon, Michael S. Kent, Ira K. Gordon |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Pathology Nose Neoplasms Antineoplastic Agents Cat Diseases Nose neoplasm Gastroenterology Disease-Free Survival Lesion Internal medicine Carcinoma medicine Animals Basal cell Retrospective Studies CATS General Veterinary business.industry Dose-Response Relationship Radiation Radiotherapy Dosage Retrospective cohort study medicine.disease stomatognathic diseases Dose–response relationship Treatment Outcome Carcinoma Squamous Cell Cats Strontium Radioisotopes Female medicine.symptom business Complication |
| Zdroj: | Journal of the American Veterinary Medical Association. 231:736-741 |
| ISSN: | 0003-1488 |
| Popis: | Objective—To determine progression-free and overall survival times of cats with squamous cell carcinoma (SCC) of the nasal planum following treatment with a single fraction of strontium Sr 90 (90Sr). Design—Retrospective case series. Animals—49 cats with SCC of the nasal planum. Procedures—Information including FIV infection status, diagnosis of SCC vs SCC in situ (ie, evidence that the tumor did or did not penetrate the epidermal basement membrane, respectively), 90Sr dose and number of probe applications, treatment-related response and complications, and recurrence of SCC and new lesion development was obtained from medical records. The relationships of these variables with calculated progression-free and overall survival times were assessed. Results—Of 49 cats that underwent 90Sr plesiotherapy (median dose, 128 Gy), 48 (98%) had a response to treatment and 43 (88%) had a complete response. Median progression-free and overall survival times were 1,710 and 3,076 days, respectively. Treatment complications were infrequent (4 [8%] cats) and mild. Following treatment, the SCC recurrence rate was 20% (10/49 cats); 16 (33%) cats developed new lesions in other locations. Overall survival time was significantly longer for cats with a complete response to treatment than for those with a partial response. None of the other variables evaluated had a significant effect on progression-free or overall survival time. Conclusions and Clinical Relevance—Treatment of cats with SCC of the nasal planum with a single fraction of 90Sr appeared to be effective and well tolerated. Initial response to treatment was predictive of overall survival time. |
| Databáze: | OpenAIRE |
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