Low frequency of HLA-B27 and scarcity of ankylosing spondylitis in a Zairean Bantu population
| Autor: | C. Kaplan, L. Hallé, A Z Lurhuma, Jan Dequeker, J. M. Mbuyi-Muamba, K. Mbayo |
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| Rok vydání: | 1998 |
| Předmět: |
musculoskeletal diseases
Adult Male Population Black People Disease Rheumatology Antigen Gene Frequency Genetic predisposition Prevalence Medicine Humans Genetic Predisposition to Disease Spondylitis Ankylosing education Spondylitis Allele frequency HLA-B27 Antigen HLA-B27 Ankylosing spondylitis education.field_of_study business.industry General Medicine medicine.disease Immunology Democratic Republic of the Congo Female business |
| Zdroj: | Clinical rheumatology. 17(4) |
| ISSN: | 0770-3198 |
| Popis: | Ankylosing spondylitis (AS) is an inflammatory rheumatic disease which is thought to be rarely seen in African Blacks. Its genetic predisposition has been stressed in Caucasians where the HLA-B27 antigen is firmly linked to the disease. In the present study, HLA-B27 antigen was determined in 146 individuals of Bantu root. Only one of these subjects was found to possess HLA-B27 antigen. This study correlates the low frequency of HLA-B27 with the observed scarcity of AS in patients attending a clinic in Kinshasa for osteoarticular diseases. |
| Databáze: | OpenAIRE |
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