BioArena System for Knowing and Understanding the Biological World: A Review with New Experimental Results
| Autor: | Péter G. Ott, Ernő Tyihák, Zsuzsa Király-Véghely, Emil Mincsovics, György Kátay, Ágnes M. Móricz |
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| Rok vydání: | 2013 |
| Předmět: |
Ozone
Formaldehyde Tetrazolium Salts Endogeny Cinnamic acid Analytical Chemistry chemistry.chemical_compound In vivo Environmental Chemistry Ions Pharmacology Antimicrobial Combinatorial chemistry Small molecule Anti-Bacterial Agents Thiazoles Biochemistry chemistry Biological Assay Chromatography Thin Layer Agronomy and Crop Science Salicylic acid Bacillus subtilis Food Science |
| Zdroj: | Journal of AOAC INTERNATIONAL. 96:1189-1199 |
| ISSN: | 1944-7922 1060-3271 |
| DOI: | 10.5740/jaoacint.sgetyihak |
| Popis: | A simple observation is the basis of the development of BioArena system: according to the first observations during the biological incubation after inoculation there is formaldehyde (HCHO) emission from the chromatographic spots; in this emission process, the level of HCHO molecules decreases time dependently. In fact, the antibiotic effect of an antibiotic-like compound decreases in parallel with the HCHO emission. The investigations demonstrated clearly a unique function and role of endogenous HCHO and its one main reaction product, ozone (O3), in the antiproliferative (e.g., antimicrobial) effect of different molecules with diverse chemical structures. The results in BioArena can be extended for in vivo conditions (e.g., greenhouse experiments), as well. For the pretreatment with different doses of inducers (immunostimulation-inducing molecules) there are always four bioequivalent immunostimulating response ranges (quadruple bioequivalent immune response system) in plants. The inducers (e.g., N-methylated basic amino acids, salicylic acid, cinnamic acid, and trace elements) do not participate directly in the induction of the immunostimulating effect. These new findings support a statement that HCHO and its reaction products (mainly O3), as bioreactive small molecules, are responsible for the immunostimulating activity (in vivo conditions), as well. |
| Databáze: | OpenAIRE |
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