Essential Thrombocythemia in Children: A Retrospective Study
| Autor: | Mahasen Saleh, Abdullah Al-Jefri, Saadiya Khan, Khawar Siddiqui, Muhammed Ameen, Abdulrahman Al-Musa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Thrombocytosis business.industry Essential thrombocythemia Incidence (epidemiology) Retrospective cohort study Anagrelide medicine.disease Pediatric ET Asymptomatic medicine Original Article JAK2 mutation medicine.symptom Family history business Stroke medicine.drug |
| Zdroj: | Journal of Hematology |
| ISSN: | 1927-1220 1927-1212 |
| DOI: | 10.14740/jh822 |
| Popis: | Background: Essential thrombocythemia (ET) is one of the “classic” Philadelphia chromosome negative (Ph-) myeloproliferative neoplasms characterized by sustained thrombocytosis, increased megakaryopoiesis and high risk of vascular complications. ET is very rare in childhood. The annual incidence is approximately 1 per 10,000,000 in children less than 14 years, and about 60 times lower than adults. The genetic landscape and clonal features in childhood ET has not been well defined. There is no evidence-based guidance on the diagnosis of childhood ET. Methods: Medical records of 28 pediatric patients (age |
| Databáze: | OpenAIRE |
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