Dementia remains the major predictor of death among octogenarians. A study of two population cohorts of 85-year-olds examined 22 years apart
| Autor: | Xinxin Guo, Mats Ribbe, Therese Rydberg Sterner, Jenna Najar, Lina Rydén, Simona Sacuiu, Anna Zettergren, Hanna Wetterberg, Hanna Falk Erhag, Silke Kern, Ingmar Skoog |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Secular trends Epidemiology Life expectancy Population Cohort Studies 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Cause of Death medicine Dementia Humans 030212 general & internal medicine Registries Mortality education Aged 80 and over Sweden education.field_of_study business.industry Mortality rate medicine.disease Neuro-Epidemiology Relative risk Cohort Attributable risk Female business 030217 neurology & neurosurgery Demography Cohort study |
| Zdroj: | European Journal of Epidemiology |
| ISSN: | 1573-7284 |
| Popis: | Dementia is the major predictor of death in old age. The aim of this paper was to determine whether 8-year mortality among 85-year olds with and without dementia, and if the contribution of dementia to mortality relative to other common diseases has changed. We used two population-based cohorts of 85-year-olds (N = 1065), born in 1901–02 and 1923–24, which were examined with identical methods in 1986–87 and 2008–2010 and followed for 8-year mortality according to data from the Swedish Tax Agency. Dementia was diagnosed according to DSM-III-R. Other diseases were diagnosed based on self-reports, close informant interviews, somatic examinations, and the Swedish National In-patient Register. Compared to cohort 1901–02, cohort 1923–24 had a lower 8-year mortality both among those with (HR 0.7; 95% CI 0.5–0.99) and without dementia (HR 0.7; 95% CI 0.5–0.9). Dementia was associated with increased mortality in both cohorts (cohort 1901–02, HR 2.6; 95% CI 2.0–3.2, cohort 1923–24, HR 2.8; 95% CI 2.3–3.5), and remained the major predictor of death, with a population attributable risk of 31.7% in 1986–87 and 27.7% in 2008–10. Dementia remained the most important predictor of death in both cohorts. The relative risk for mortality with dementia did not change between cohorts, despite a decreased mortality rate in the population. Supplementary Information The online version contains supplementary material available at 10.1007/s10654-021-00745-5. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink