Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents
| Autor: | A M Venuat, F Nasr, Patrice Carde, Elisabeth Macintyre, C Bayle, Vincent Ribrag |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Cancer Research medicine.medical_treatment Chromosomal translocation Biology Translocation Genetic Recurrence hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols Proto-Oncogenes medicine Neoplasm Humans Topoisomerase II Inhibitors neoplasms Etoposide Gene Rearrangement Chemotherapy Topoisomerase Chromosomes Human Pair 11 Remission Induction Hematology Gene rearrangement Histone-Lysine N-Methyltransferase Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Molecular biology Antineoplastic Agents Phytogenic DNA-Binding Proteins Oncology Fusion transcript Drug Resistance Neoplasm biology.protein Myeloid-Lymphoid Leukemia Protein Female Topoisomerase-II Inhibitor Transcription Factors |
| Zdroj: | Leukemialymphoma. 25(3-4) |
| ISSN: | 1042-8194 |
| Popis: | Secondary therapy-related, acute lymphoblastic leukemia (S-ALL) is less common than its myeloblastic counterpart. S-ALL with MLL gene rearrangements have only been reported on six previous occasions. Only three of these had t(4;11)(q21;23) S-ALL with MLL-AF4 fusion transcript has only been reported in one earlier case. In this report a rare case of S-ALL with MLL-AF4 transcript is described in a 36 year old woman treated for breast carcinoma with chemotherapy which included the topoisomerase II inhibitor, VP-16. The precise incidence of MLL gene rearrangement in S-ALL still remains to be clarified. |
| Databáze: | OpenAIRE |
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