Diuretic-gene interaction and the risk of myocardial infarction and stroke
| Autor: | Albert Hofman, J. C. M. Witteman, C M van Duijn, Olaf H. Klungel, A. de Boer, Monique M.B. Breteler, H Schelleman, B.H.Ch. Stricker |
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| Přispěvatelé: | Epidemiology, Cardiology |
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Myocardial Infarction Risk Assessment Rotterdam Study Gene Frequency Gene interaction Risk Factors Internal medicine Genetics Humans Medicine Genetic Predisposition to Disease Prospective Studies Myocardial infarction Diuretics Aged Netherlands Proportional Hazards Models Pharmacology Polymorphism Genetic business.industry Proportional hazards model Hazard ratio Middle Aged medicine.disease Heterotrimeric GTP-Binding Proteins Confidence interval Stroke Population Surveillance Hypertension Cardiology Molecular Medicine Calmodulin-Binding Proteins Female Diuretic business Follow-Up Studies GNB3 |
| Zdroj: | Pharmacogenomics Journal, 7(5), 346-352. Nature Publishing Group |
| ISSN: | 1470-269X |
| Popis: | This study investigates whether the interaction between diuretics and alpha-adducin (ADD1) G460W or G-protein beta3-subunit (GNB3) rs2301339 polymorphism modifies the risk of myocardial infarction (MI) or stroke. Data were used from the Rotterdam Study. The drug-gene interaction was determined with a Cox proportional hazard model with adjustment for each drug class as time-dependent covariates. The risk of MI in current users of low-ceiling diuretics with one or two copies of the ADD1 W-allele (hazard ration (HR)=0.92) was similar compared to the expected joint effect of the W-allele and low-ceiling diuretics on a multiplicative scale (1.04 x 0.90=0.94) (synergy index (SI):0.99; 95% confidence interval (CI): 0.43-2.27). No drug-gene interaction was found on the risk of stroke (SI:0.66; 95% CI:0.43-1.27). In addition, a trend towards an interaction was found between current use and the GNB3 rs230119 G/A polymorphism on the risk of MI (SI: 0.51; 95% CI: 0.23-1.15), whereas no interaction on the risk of stroke was found (SI: 0.84; 95% CI: 0.46-1.56). |
| Databáze: | OpenAIRE |
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