Imaging biomarkers of outcome after radiotherapy for pediatric ependymoma
| Autor: | Stéphane Supiot, Valérie Bernier, Elisabeth Le Prisé, Anne-Isabelle Bertozzi-Salamon, Anne Ducassou, Annick Sevely, Patrice Péran, Anne Laprie, A. Jouin, Laetitia Padovani, Léonor Chaltiel, Claire Alapetite, Jean Albert Lotterie, F. Tensaouti, Christine Kerr, Line Claude, Samuel Liceaga, Stéphanie Bolle, Aymeri Huchet |
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| Rok vydání: | 2018 |
| Předmět: |
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Ependymoma medicine.medical_specialty Neoplasm Residual Multivariate analysis Adolescent medicine.medical_treatment Brain tumor Fluid-attenuated inversion recovery Disease-Free Survival Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Pediatric ependymoma Postoperative Period Child Retrospective Studies Univariate analysis Brain Neoplasms business.industry Infant Hematology Prognosis medicine.disease Magnetic Resonance Imaging Hyperintensity Tumor Burden Radiation therapy Treatment Outcome Oncology Child Preschool 030220 oncology & carcinogenesis Multivariate Analysis Female Radiotherapy Adjuvant Radiology business 030217 neurology & neurosurgery |
| Zdroj: | Radiotherapy and Oncology. 127:103-107 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2018.02.008 |
| Popis: | Background and purpose Ependymoma is the third most common brain tumor in children. Radiation therapy (RT) is systematically administered after maximum surgical resection, utilizing recent advances in radiation delivery. Imaging can make a significant contribution to improving treatment outcome. This prompted us to look for significant preoperative and postoperative imaging markers for survival. Material and methods We undertook a national retrospective review of 121 patients who had undergone resection followed by RT. Preoperative tumor volumes on T1 and FLAIR images were delineated, together with postoperative hyperintense volumes on FLAIR images. Overall survival (OS) and disease-free survival (DFS) analyses included clinical data and volumes extracted from images. Results After a median follow-up of 38.5 months, 80.2% of patients were alive, but 39.7% had experienced at least one event. Statistically significant differences between patients with and without postoperative FLAIR abnormalities were found for both DFS (71.9% vs. 40.3%; p = 0.006) and OS (93.7% vs. 72.4%; p = 0.023) in the univariate analyses, and for OS (p = 0.049) in the multivariate analyses. Conclusions Postoperative FLAIR hyperintensities are a negative prognostic factor for intracranial ependymoma and may be a surrogate for residual disease. They could therefore prove helpful in patients' surgical and radiotherapeutic management. |
| Databáze: | OpenAIRE |
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