Neuroinflammatory
| Autor: | Ye Peng, Shifeng Chu, Yantao Yang, Zhao Zhang, Zongran Pang, Naihong Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cell
neurological disorders blood brain barrier cell lines Review RM1-950 Blood–brain barrier neuroinflammation Immune system microglial cells In vivo Medicine Pharmacology (medical) Neuroinflammation Pharmacology N9 cell business.industry General Commentary glial cell co-culture medicine.anatomical_structure Cell culture BV-2 cell Therapeutics. Pharmacology business Neuroscience Immortalised cell line In vitro cell culture |
| Zdroj: | Frontiers in Pharmacology, Vol 12 (2021) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2021.671734/full |
| Popis: | Cell cultures are used in pharmaceutical, medical and biological sciences. Due to the ethical and cost limitations of in vivo models, the replaceable cell model that is more closely related to the characteristics of organisms, which has broad prospects and can be used for high-throughput drug screening is urgent. Neuronal and glial cell models have been widely used in the researches of neurological disorders. And the current researches on neuroinflammation contributes to blood-brain barrier (BBB) damage. In this review, we describe the features of healthy and inflamed BBB and summarize the main immortalized cell lines of the central nervous system (PC12, SH-SY5Y, BV2, HA, and HBMEC et al.) and their use in the anti-inflammatory potential of neurological disorders. Especially, different co-culture models of neuroinflammatory, in association with immune cells in both 2D and 3D models are discussed in this review. In summary, 2D co-culture is easily practicable and economical but cannot fully reproduce the microenvironment in vivo. While 3D models called organs-on-chips or biochips are the most recent and very promising approach, which made possible by bioengineering and biotechnological improvements and more accurately mimic the BBB microenvironment. |
| Databáze: | OpenAIRE |
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