Přispěvatelé: |
[Chaves Conde,M, Moreno Nogueira,JA] Servicio de Oncología Médica, Hospital Universitario Virgen del Rocío, Sevilla. [Ramirez-Lorca,R, Molero,E, Ruiz,A, Real,LM, Royo,JL] Departamento de Genómica Estructural, Neocodex SL, Sevilla. [Esteban Lopez-Jamar,JM, Ramírez-Armengol,JA] Servicio de Endoscopia, Hospital Clínico San Carlos, Madrid. [Hidalgo Pascual,M] Servicio de Cirugía General-B, Hospital Universitario 12 de Octubre, Madrid. [García Martín-Córdoba,C] Hospital Ramón y Cajal, Madrid, Spain., This study was supported by Ministerio de Ciencia y Tecnologia (the Spanish Ministry of Science and Technology) PROFIT 010000-2004-69. |
Popis: |
Journal Article; Research Support, Non-U.S. Gov't; Caveolae are involved in physical compartmentalization between different groups of signaling events. Its main component, CAV1, modulates different pathways in cellular physiology. The emerging evidence pointing to the role of CAV1 in cancer led us to study whether different alleles of this gene are associated with colorectal cancer (CRC). Since one of the most characterized enzymes regulated by CAV1 is eNOS, we decided to include both genes in this study. We analyzed five SNPs in 360 unrelated CRC patients and 550 controls from the general population. Two of these SNPs were located within eNOS and three within the CAV1 gene. Although haplotype distribution was not associated with CRC, haplotype TiA (CAV1) was associated with familiar forms of CRC (p |