Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer

Autor: Eva Molero, Manuel Chaves Conde, Luis Miguel Real, Carlos García Martín-Cordova, Jose Miguel Esteban Lopez-Jamar, José Andrés Moreno Nogueira, Jose Luis Royo, Juan Andres Ramírez-Armengol, Manuel Hidalgo Pascual, Reposo Ramírez-Lorca, Agustín Ruiz
Přispěvatelé: [Chaves Conde,M, Moreno Nogueira,JA] Servicio de Oncología Médica, Hospital Universitario Virgen del Rocío, Sevilla. [Ramirez-Lorca,R, Molero,E, Ruiz,A, Real,LM, Royo,JL] Departamento de Genómica Estructural, Neocodex SL, Sevilla. [Esteban Lopez-Jamar,JM, Ramírez-Armengol,JA] Servicio de Endoscopia, Hospital Clínico San Carlos, Madrid. [Hidalgo Pascual,M] Servicio de Cirugía General-B, Hospital Universitario 12 de Octubre, Madrid. [García Martín-Córdoba,C] Hospital Ramón y Cajal, Madrid, Spain., This study was supported by Ministerio de Ciencia y Tecnologia (the Spanish Ministry of Science and Technology) PROFIT 010000-2004-69.
Rok vydání: 2006
Předmět:
Male
Cancer Research
Polimorfismo de nucleótido simple
Colorectal cancer
Caveolin 1
Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]
Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes [Medical Subject Headings]
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Caveolin-1
Enos
Masculino
Genetics
education.field_of_study
biology
Pyrosequencing
Predisposición genética a la enfermedad
General Medicine
Middle Aged
Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease [Medical Subject Headings]
Oncology
eNOS
Female
Haplotipos
Alelos
Colorectal Neoplasms
Nitric Oxide Synthase Type III
Anciano
Population
Check Tags::Male [Medical Subject Headings]
Single-nucleotide polymorphism
Chemicals and Drugs::Amino Acids
Peptides
and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins
Signal Transducing::Caveolin 1 [Medical Subject Headings]
Polymorphism
Single Nucleotide
Heritability
medicine
Humans
Genetic Predisposition to Disease
Caveolina 1
Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]
Allele
education
Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings]
Alleles
Aged
Mediana edad
Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism
Genetic::Polymorphism
Single Nucleotide [Medical Subject Headings]
Haplotype
Cancer
Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [Medical Subject Headings]
biology.organism_classification
medicine.disease
digestive system diseases
Haplotypes
Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amino Acid Oxidoreductases::Nitric Oxide Synthase::Nitric Oxide Synthase Type III [Medical Subject Headings]
Óxido nítrico sintasa de tipo III
Zdroj: Oncology reports. 16(2)
ISSN: 1021-335X
Popis: Journal Article; Research Support, Non-U.S. Gov't; Caveolae are involved in physical compartmentalization between different groups of signaling events. Its main component, CAV1, modulates different pathways in cellular physiology. The emerging evidence pointing to the role of CAV1 in cancer led us to study whether different alleles of this gene are associated with colorectal cancer (CRC). Since one of the most characterized enzymes regulated by CAV1 is eNOS, we decided to include both genes in this study. We analyzed five SNPs in 360 unrelated CRC patients and 550 controls from the general population. Two of these SNPs were located within eNOS and three within the CAV1 gene. Although haplotype distribution was not associated with CRC, haplotype TiA (CAV1) was associated with familiar forms of CRC (p
Databáze: OpenAIRE
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