Remembering to remember: T cell memory maintenance and plasticity
| Autor: | Kyla D. Omilusik, Ananda W. Goldrath |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Epigenomics
0301 basic medicine 1.1 Normal biological development and functioning T cell Immunology Population Cell CD8-Positive T-Lymphocytes Biology Lymphocyte Activation Article Epigenesis Genetic Vaccine Related 03 medical and health sciences 0302 clinical medicine Genetic Antigen Underpinning research T-Lymphocyte Subsets medicine Animals Humans Immunology and Allergy education Epigenesis education.field_of_study Effector Prevention Cell Differentiation Phenotype 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Immunologic Memory Neuroscience CD8 030215 immunology |
| Zdroj: | Curr Opin Immunol |
| ISSN: | 0952-7915 |
| DOI: | 10.1016/j.coi.2019.04.009 |
| Popis: | Upon activation, naive T cells give rise to a heterogeneous cell population of effector and memory T cells that mediate antigen clearance and provide long-lived protection from rechallenge. Many of the transcriptional regulators that direct the differentiation of naive T cells to acquire the range of phenotypic and functional characteristics of effector and memory T cells have been described. However, the active programs that maintain the specific subsets of memory T cells are less clear. Here, we discuss recent studies that suggest effector and memory CD8(+) T cells exist in cellular ‘states’ with inherent plasticity. Further, we consider the newly identified role of active transcriptional and epigenetic programming in maintaining the identity of the distinct subsets within the memory population. |
| Databáze: | OpenAIRE |
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