Pyrazole derivatives as antitumor, anti-inflammatory and antibacterial agents
| Autor: | Xin Zhang, Hai-Liang Zhu, Xin Zhao, Jia-Jia Liu, Meng-yue Zhao |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
Drug biology Chemistry Kinase medicine.drug_class media_common.quotation_subject Rational design Anti-Inflammatory Agents Antineoplastic Agents General Medicine Pyrazole Small molecule Receptor tyrosine kinase Anti-inflammatory Anti-Bacterial Agents chemistry.chemical_compound Biochemistry Drug Discovery biology.protein medicine Humans Pyrazoles media_common |
| Zdroj: | Mini reviews in medicinal chemistry. 13(13) |
| ISSN: | 1875-5607 |
| Popis: | Within the past years, many researches on the synthesis, structure-activity relationships (SAR), antitumor, antiinflammatory and anti-bacterial activities of the pyrazole derivatives have been reported. Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAF(V600E), EGFR, telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory and anti-bacterial activities. In this review, the bioactivities of the pyrazole derivatives mentioned above will be summarized in detail. We sincerely hope that increasing knowledge of the SAR and cellular processes underlying the bioactivity of pyrazole derivatives will be beneficial to the rational design of new generation of small molecule drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|