Scaling Up Attrition-Enhanced Deracemization by Use of an Industrial Bead Mill in a Route to Clopidogrel (Plavix)

Autor:	Wim L. Noorduin, Richard M. Kellogg, G. Deroover, Bernard Kaptein, M.W. van der Meijden, Arno A. C. Bode, Elias Vlieg, P. van der Asdonk, Hugo Meekes, W.J.P. van Enckevort
Přispěvatelé:	Stratingh Institute of Chemistry
Rok vydání:	2010
Předmět:	Materials science Stereochemistry Organic Chemistry Solid State Chemistry medicine.disease Grinding Bead (woodworking) Enantiopure drug Chemical engineering medicine Mill Attrition Physical and Theoretical Chemistry Racemization Scaling
Zdroj:	Organic Process Research & Development, 14, 4, pp. 908-911 Organic Process Research & Development, 14(4), 908-911. AMER CHEMICAL SOC INC Organic Process Research & Development, 14, 908-911
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op1001116
Popis:	The recently discovered technique of deracemization by means of grinding a racemic conglomerate in contact with a solution wherein racemization occurs has been scaled up using an industrial bead mill to demonstrate the practical applicability. The time needed to reach the enantiopure end state is drastically reduced as a result of the efficient grinding that can be achieved using bead mills.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41431e994fc0e0059eb8daf3fc4d42e9 https://doi.org/10.1021/op1001116 Zobrazit plný text záznamu