Exploratory Study on the Effects of Treatment with Two Mistletoe Preparations on Chronic Hepatitis C
| Autor: | Karel Jan Tusenius, Jan van Hattum, Anne Marie Spoek |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Loranthaceae Antiviral Agents Gastroenterology Liver Function Tests Internal medicine Drug Discovery medicine Viscum album Humans Aspartate Aminotransferases Aged Plant Proteins medicine.diagnostic_test biology Plant Extracts business.industry Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease biology.organism_classification Mistletoe Area Under Curve Immunology Quality of Life RNA Viral Elevated transaminases Female Liver cancer business Liver function tests Viral load |
| Zdroj: | Arzneimittelforschung. 55:749-753 |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1296925 |
| Popis: | Twenty-one patients with chronic hepatitis C were treated with a mistletoe preparation as monotherapy (either Iscador or Abnoba viscum) during one year. The treatment was well tolerated. Patients entering the study with elevated transaminases had a significant improvement, both for AST (aspartate aminotransferase) (p = 0.01) and for ALT (alanine aminotransferase) (p = 0.04). Quality of life significantly improved (p = 0.006) in patients with a low initial quality of life. Although one patient obtained a complete virological response, few effects on viral load were seen in the whole group. These results suggest an effect comparable to glycyrrhicin treatment: improvement of liver inflammation and thus possibly reduction of the long term complications, viz cirrhosis and liver cancer. Mistletoe preparations have the advantage of easy administration and low cost. |
| Databáze: | OpenAIRE |
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