Can mixed pure hepatocellular carcinoma and germinoma arise together in the brain?
| Autor: | Shih-Chieh Lin, Yi-Wei Chen, Wan-Yuo Guo, Kai Ping Chang, I-Chun Lai, Tai-Tong Wong, Ming-Teh Chen, Sang-Hue Yen, Donald Ming-Tak Ho, Lu-Jen Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Liver tumor Carcinoma Hepatocellular Adolescent medicine.medical_treatment pediatric brain tumor germinoma medicine Combined Modality Therapy Humans Pathological radiotherapy germ-cell tumor Chemotherapy Adjuvant radiotherapy lcsh:R5-920 Germinoma business.industry Brain Neoplasms General Medicine hepatocellular carcinoma Neoplasms Germ Cell and Embryonal medicine.disease Radiation therapy Hepatocellular carcinoma Female business lcsh:Medicine (General) |
| Zdroj: | Journal of the Chinese Medical Association, Vol 78, Iss 9, Pp 562-566 (2015) |
| ISSN: | 1726-4901 |
| Popis: | Intracranial germ-cell tumors (GCTs) represent 10–15% of all pediatric brain tumors in East Asia. There is a wide histopathological spectrum of intracranial GCTs. Germinomas and nongerminomatous GCTs are the two major classifications. It is difficult to distinguish different subtypes of intracranial GCTs based solely on imaging studies, however, some tumor markers, such as α-fetoprotein or β-human chorionic gonadotropin, are helpful for diagnosis. In this study we present the case of a 13-year-old girl with an intracranial mixed GCT containing a hepatocellular carcinoma and germinoma without a primary liver tumor. Based on this unique pathological diagnosis, a series of treatments were applied, including surgery for gross tumor removal, adjuvant radiotherapy, and chemotherapy. Long-term follow up indicates fair disease control. |
| Databáze: | OpenAIRE |
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