Plasmic score applicability for the diagnosis of thrombotic microangiopathy associated with ADAMTS13-acquired deficiency in a developing country
| Autor: | Herivaldo Ferreira da Silva, Maria Allyce de Oliveira, Tadeu Gonçalves de Lima, Natália P. Boris, Suzanna A. Tavares Barbosa, Deivide de Sousa Oliveira, Fernanda Luna Neri Benevides |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Thrombotic microangiopathy TTP Thrombotic thrombocytopenic purpura Developing country Plasmic Adamts13 activity aHUS hemic and lymphatic diseases Internal medicine Immunology and Allergy Acquired deficiency Medicine lcsh:RC633-647.5 business.industry Retrospective cohort study lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease ADAMTS13 cardiovascular system Fatal disease Original Article business |
| Zdroj: | Hematology, Transfusion and Cell Therapy, Vol 41, Iss 2, Pp 119-124 (2019) Hematology, Transfusion and Cell Therapy, Volume: 41, Issue: 2, Pages: 119-124, Published: 10 JUN 2019 Hematology, Transfusion and Cell Therapy |
| ISSN: | 2531-1379 |
| DOI: | 10.1016/j.htct.2018.10.002 |
| Popis: | Background: Thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disease that requires early diagnosis and treatment that can be made possible by applying the PLASMIC score. This study aims to evaluate this score applicability for patients with suspected TTP in a developing country. Methods: This was a retrospective study performed at a tertiary hospital in the northeastern region of Brazil. Patients were analyzed in two groups: ADAMTS13 activity 10%. Patients were stratified according to the PLASMIC score, and the level of agreement between the PLASMIC score and the ADAMTS13 activity was evaluated. Results: Eight patients with thrombotic microangiopathy were included. Four patients had ADAMTS13 activity 10%, all with a score |
| Databáze: | OpenAIRE |
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