'Omics' Signatures in Peripheral Monocytes from Women with Low BMD Condition
| Autor: | M. Ikram Khatkhatay, Bhavna Daswani |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Bone density Transendothelial migration business.industry Endocrinology Diabetes and Metabolism Monocyte lcsh:R lcsh:Medicine Chemotaxis Review Article Omics Bone resorption Peripheral 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology medicine.anatomical_structure Osteoclast 030220 oncology & carcinogenesis medicine Cancer research business |
| Zdroj: | Journal of Osteoporosis Journal of Osteoporosis, Vol 2018 (2018) |
| ISSN: | 2090-8059 |
| Popis: | Postmenopausal osteoporosis (PMO) is a result of increased bone resorption compared to formation. Osteoclasts are responsible for bone resorption, which are derived from circulating monocytes that undertake a journey from the blood to the bone for the process of osteoclastogenesis. In recent times, the use of high throughput technologies to explore monocytes from women with low versus high bone density has led to the identification of candidate molecules that may be deregulated in PMO. This review provides a list of molecules in monocytes relevant to bone density which have been identified by “omics” studies in the last decade or so. The molecules in monocytes that are deregulated in low BMD condition may contribute to processes such as monocyte survival, migration/chemotaxis, adhesion, transendothelial migration, and differentiation into the osteoclast lineage. Each of these processes may be crucial to the overall route of osteoclastogenesis and an increase in any/all of these processes can lead to increased bone resorption and subsequently low bone density. Whether these molecules are indeed the cause or effect is an arena currently unexplored. |
| Databáze: | OpenAIRE |
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