Direct determination of absolute stereochemistry of α-methylselenocysteine using the Mosher method

Autor:	Douglas S. Masterson, Robert J. Wehrle, Douglas R. Powell
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Steric effects Methylselenocysteine chemistry.chemical_compound Chemistry Mosher analysis Stereochemistry General Chemistry Unnatural amino acids QD1-999 NMR Determination of stereochemistry
Zdroj:	Results in Chemistry, Vol 3, Iss, Pp 100114-(2021)
ISSN:	2211-7156
Popis:	Mosher amides of α-methylselenocysteine were synthesized to determine the absolute stereochemistry of the sterically hindered α-carbon utilizing 1H, 13C, 19F, and 77Se NMR spectroscopies. After analysis of these spectra using the established Mosher method, the stereochemistry of the α-carbon was determined to be (R), which was subsequently confirmed using x-ray crystallography.
Databáze:	OpenAIRE
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