Early-life imprinting of unconventional T cells and tissue homeostasis

Autor:	Michael G. Constantinides, Yasmine Belkaid
Rok vydání:	2021
Předmět:	Inflammation Multidisciplinary T-Lymphocyte Subsets Microbiota Histocompatibility Antigens Class I Animals Homeostasis Humans Natural Killer T-Cells Immunity Innate Mucosal-Associated Invariant T Cells Article
Zdroj:	Science
ISSN:	1095-9203 0036-8075
Popis:	Atypical T cells take a different path Conventional T cells recognize peptides that are presented by polymorphic major histocompatibility complexes (MHCs). By contrast, many tissue-resident T cells, such as mucosal-associated invariant T cells, invariant natural killer T cells, and γδ T cells, respond to modified peptides and small molecules presented by conserved MHC-like molecules. Unconventional T cells are important for host defense and tissue repair and seed tissues during critical early-life windows of development. Constantinides and Belkaid review recent advances describing how unconventional T cell subsets compete for early-life signals, including those from the microbiota, which instruct their development and have enduring consequences for the health of the host. —STS
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413fa8d6f40b01fc21c0099eb636e78f https://doi.org/10.1126/science.abf0095 Zobrazit plný text záznamu