Control of aromatase in breast cancer cells and its importance for tumor growth
| Autor: | Mitchell Dowsett, Judith Gledhill, J. Alan McKinna, Alan Ashworth, Ian E. Smith, Joanne E. Nicholls, Carolyn M. Ryde, Valentine M. Macaulay |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Mammary gland Breast Neoplasms Biochemistry Aromatase Endocrinology In vivo Internal medicine Tumor Cells Cultured medicine Humans Testosterone skin and connective tissue diseases Autocrine signalling Molecular Biology Aromatase inhibitor Dose-Response Relationship Drug Epidermal Growth Factor Fadrozole biology Cell growth Cell Biology Transfection Transforming Growth Factor alpha medicine.anatomical_structure Bucladesine biology.protein Molecular Medicine Female Cell Division Tamoxifen medicine.drug |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 44:605-609 |
| ISSN: | 0960-0760 |
| DOI: | 10.1016/0960-0760(93)90266-y |
| Popis: | Three approaches have been taken to elucidate further the biological importance of intratumoural aromatase activity. (i) MCF7 and T47D hormone-dependent breast cancer cell lines both showed detectable aromatase activity in vitro. The up-regulation of this by TGF alpha indicates the possible existence of an autocrine growth stimulatory loop involving aromatase. (ii) Both tamoxifen and cytotoxic chemotherapy caused the suppression of aromatase activity in breast carcinomas in vivo. Aromatase activity prior to treatment did not predict for clinical response to tamoxifen. (iii) Transfection of aromatase into MCF7 cells led to their growth being stimulated by low doses of androgens and this was inhibited by the aromatase inhibitor CGS 16949A. |
| Databáze: | OpenAIRE |
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