Prolonged decrease of serum prolactin in rat by an ester prodrug of apomorphine
| Autor: | Robert J. Borgman, N. S. Kula, Ross J. Baldessarini, A. E. Boyd |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Apomorphine Endocrinology Diabetes and Metabolism Pharmacology Esterase Receptors Dopamine Serum prolactin Endocrinology Ester prodrug Internal medicine medicine Animals Biological Psychiatry Estradiol Endocrine and Autonomic Systems Chemistry Dopaminergic Esters Prodrug Prolactin Rats Psychiatry and Mental health medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 4(2) |
| ISSN: | 0306-4530 |
| Popis: | (1) An O , O ′-diester of apomorphine mimicked the prolactin-lowering action of apomorphine in the estrogen-primed male rat. (2) Its effects were somewhat slower in onset, but much longer-lasting than those of apomorphine. (3) These effects closely parallel previously observed long-lasting behavioral effects in rodents following the administration of apomorphine esters. (4) We believe these effects are mediated by central dopaminergic actions of apomorphine slowly liberated from these ester “prodrugs” by esterase hydrolysis. |
| Databáze: | OpenAIRE |
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