Comparative effects of endothelin (ET-1) and U46619 on human saphenous vein and gastroepiploic artery, sources of human autologous grafts
| Autor: | R. M. Saroyan, Dennis B. McNamara, R. K. Minkes, Peter Kvamme, Lawrence S. Fox, Norman Rowe, Watts R. Webb, Philip J. Kadowitz, Noel L. Mills, Morris D. Kerstein, Jerry T. Light |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Clinical Biochemistry Gastroepiploic Artery In Vitro Techniques Revascularization Transplantation Autologous Thromboxane A2 chemistry.chemical_compound Internal medicine medicine Humans Saphenous Vein Vein Molecular Biology business.industry Endothelins Vasospasm Cell Biology General Medicine Arteries medicine.disease Endothelin 1 Prostaglandin Endoperoxides Synthetic medicine.anatomical_structure chemistry cardiovascular system Cardiology business Endothelin receptor Digestive System Artery |
| Zdroj: | Molecular and cellular biochemistry. 117(1) |
| ISSN: | 0300-8177 |
| Popis: | The effects of endothelin (ET-1) on smooth muscle contractile activity were investigated and compared in human saphenous vein and gastroepiploic artery, vessels frequently used in revascularization procedures. ET-1 contracted saphenous vein and gastroepiploic artery in a concentration-dependent manner. The peptide produced a greater maximal effect in the vein than in the artery and, in both preparations, ET-1 was less efficacious than U46619, an agent which mimics the actions of thromboxane A2 at the thromboxane A2/prostaglandin HZ receptor. The contractile response to ET-1 declined spontaneously at a more rapid rate in the artery than in the vein. The present data indicate that ET-1 has significant contractile activity in both vessels which are used for coronary arterial bypass surgery and suggest that although, a weaker vasoconstrictor than U46619, the peptide could induce vasospasm in both graft vessels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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