Prognosis and Clinicopathology of CXCR4 in Colorectal Cancer Patients: a Meta-analysis
| Autor: | Ai-Hua Wang, Jing Wang, Qing-Yin Kong, Peng Tan, Kai-Tong Jiang, Lu-Ning Li, Cui-Yue Wang, Hua-Rong Lu |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Receptors CXCR4 Epidemiology Colorectal cancer Cochrane Library Internal medicine medicine Biomarkers Tumor Humans Neoplasm Invasiveness Stage (cooking) Neoplasm Staging business.industry Hazard ratio Public Health Environmental and Occupational Health Case-control study Cancer Odds ratio medicine.disease Prognosis Meta-analysis Case-Control Studies business Colorectal Neoplasms |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(9) |
| ISSN: | 2476-762X |
| Popis: | The chemokine receptor 4 (CXCR4) has been widely used in diagnosis and prognosis of colorectal cancer (CRC). However, there is no current consensus on the impact of CXCR4 on CRC patients. The purpose of this study was to evaluate the prognostic and clinicopathological importance of CXCR4 in CRC patients. Databases, such as PubMed, Cochrane library, CBM and EMBASE updated to 2014 were searched to include eligible articles. We analysed correlations between CXCR4 expression and clinicopathological features and overall survival (OS). A total of 1, 055 CRC patients from twelve studies were included in the study. The pooled odds ratios (ORs) which indicated CXCR4 expression was likely to be associated with TNM stage (OR=0.43, CI=0.34-0.55, P |
| Databáze: | OpenAIRE |
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