The magnitude and significance of Ca2+ domains for release of neurotransmitter
| Autor: | S, Aharon, H, Parnas, I, Parnas |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Nerve Endings
Pharmacology Neurotransmitter Agents General Mathematics General Neuroscience Models Neurological Immunology General Biochemistry Genetics and Molecular Biology Membrane Potentials Kinetics Computational Theory and Mathematics Animals Calcium Computer Simulation Calcium Channels General Agricultural and Biological Sciences Mathematics Software General Environmental Science |
| Zdroj: | Bulletin of Mathematical Biology. 56:1095-1119 |
| ISSN: | 1522-9602 0092-8240 |
| DOI: | 10.1007/bf02460288 |
| Popis: | It is now widely accepted that localized high concentrations of Ca2+ (Ca2+ domains) play a major role in controlling the time course of neurotransmitter release. In the present work we calculate the magnitude and the time course of Ca2+ domains that evolve in the vicinity of a Ca2+ channel and an adjacent release site. In the calculations we consider a accurately dimensioned Ca2+ channel. Moreover, the Ca2+ current is continuously adjusted with regard to the accumulated intracellular Ca2+ and, in addition, endogenous buffers are considered. The calculations, carried out by the software FIDAP, based on finite element method, show that the Ca2+ concentrations achieved near the release sites are significantly lower than claimed by other investigators. Furthermore, we present arguments indicating that the Ca2+ domains, regardless of their magnitude, do not play a role in controlling the time course of release of neurotransmitter. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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