Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice
| Autor: | Sarah J. Bailey, Christopher P Bailey, Abdulrahman Mohammed I Almatroudi, Stephen M. Husbands |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Agonist Elevated plus maze medicine.drug_class Narcotic Antagonists Receptors Opioid mu mu agonist Pharmacology κ-opioid receptor Article Naltrexone Mice medicine Animals kappa antagonist Pharmacology (medical) kappa opioid receptor Maze Learning Depression Receptors Opioid kappa Antagonist anxiety Antidepressive Agents Conditioned place preference Buprenorphine Analgesics Opioid Disease Models Animal Psychiatry and Mental health Drug Therapy Combination Psychology Opioid antagonist medicine.drug |
| Zdroj: | Almatroudi, A, Husbands, S M, Bailey, C P & Bailey, S J 2015, ' Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice ', Journal of Psychopharmacology, vol. 29, no. 7, pp. 812-821 . https://doi.org/10.1177/0269881115586937 |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | Opiates have been used historically for the treatment of depression. Renewed interest in the use of opiates as antidepressants has focused on the development of kappa opioid receptor (κ-receptor) antagonists. Buprenorphine acts as a partial µ-opioid receptor agonist and a κ-receptor antagonist. By combining buprenorphine with the opioid antagonist naltrexone, the activation of µ-opioid receptors will be reduced and the κ-antagonist properties enhanced. We have established that a combination dose of buprenorphine (1 mg/kg) with naltrexone (1 mg/kg) functions as a short-acting κ-antagonist in the mouse tail withdrawal test. Furthermore, this dose combination is neither rewarding nor aversive in the conditioned place preference paradigm, and is without significant locomotor effects. We have shown for the first time that systemic co-administration of buprenorphine (1 mg/kg) with naltrexone (1 mg/kg) in CD-1 mice produced an antidepressant-like response in behaviours in both the forced swim test and novelty induced hypophagia task. Behaviours in the elevated plus maze and light dark box were not significantly altered by treatment with buprenorphine alone, or in combination with naltrexone. We propose that the combination of buprenorphine with naltrexone represents a novel, and potentially a readily translatable approach, to the treatment of depression. |
| Databáze: | OpenAIRE |
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