Pharmacological Experimental Study Of The Anti-Depressant Effect Of Total Saikosaponins
| Autor: | Haijun Ding, Chunmei Cao, Yu Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Choleretic Analgesic total saikosaponins tail suspension test forced swimming test Motor Activity Mice chemistry.chemical_compound Drug Discovery medicine Animals Humans Oleanolic Acid Oleanolic acid Behavior Animal Traditional medicine Depression business.industry Saponins Reserpine Research Papers Antidepressive Agents Tail suspension test Thin-layer chromatography Disease Models Animal Hindlimb Suspension Complementary and alternative medicine chemistry Antagonism business Drugs Chinese Herbal medicine.drug Behavioural despair test |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines; Vol 11, No 2 (2014); 280-284 |
| ISSN: | 0189-6016 |
| Popis: | Background : Chai Hu has the hepato-protective, choleretic, anti-tussive, analgesic, anti-inflammatory, anti-viral, hypotensive, hypolipidemic, and anti-tumor pharmacological effects. In this study, the objective of this paper was to study the anti-depressant effect of total saikosaponins. Materials and Methods : Total saikosaponins were extracted by reflux method, and were identified by thin layer chromatography (TLC). The anti-depressant effect of total saikosaponins was investigated in vitro by tail suspension test, forced swimming test, and reserpine antagonism test in mice. Results : Two times of reflux extraction, temperature of 70℃, and extraction time of 4hrs, for each extraction could improve the yield of saikosaponins. Each treatment group (100, 200, and 300 mg/kg), could significantly shorten the immobility time of mice in the tail suspension test in a somewhat dose-dependent manner. The total saikosaponins antagonized the reserpine-induced akinesia, and ptosis in mice. Conclusion : Total saikosaponins have an anti-depressant effect. Key words : total saikosaponins; tail suspension test; forced swimming test |
| Databáze: | OpenAIRE |
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