Pharmacokinetics of Daptomycin in Critically Ill Pediatric Patients
| Autor: | Evangelos Gikas, Paschalis Kadiltzoglou, Eirini Baira, Emmanuel Roilides, George Briassoulis, Aristides Dokoumetzidis, Eleni Volakli, Maria Sdougka, Charalampos Antachopoulos, Stavroula Ilia |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Drug Adolescent Critical Illness media_common.quotation_subject 030106 microbiology Sepsis 03 medical and health sciences 0302 clinical medicine Daptomycin Pharmacokinetics 030225 pediatrics medicine Humans Pharmacology (medical) Child media_common Pharmacology Time zero medicine.diagnostic_test Critically ill business.industry medicine.disease Anti-Bacterial Agents Infectious Diseases Therapeutic drug monitoring Anesthesia Female Once daily Burns business medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 62 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.02462-17 |
| Popis: | The pharmacokinetics of daptomycin (10 mg/kg once daily) was studied in 4 critically ill pediatric patients aged 8 to 14 yrs. The area under the concentration-time curve from time zero to infinity (AUC 0–∞ ) of plasma concentrations on day 1 ranged between 123.8 to 663.9 μg · h/ml, with lower values observed in septic and burn patients; clearance ranged from 15.1 to 80.7 ml/h/kg. Higher-than-recommended doses of daptomycin may be needed in septic children to ensure optimal drug exposure. Interpatient variability may suggest a role for therapeutic drug monitoring. |
| Databáze: | OpenAIRE |
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