Similar cytogenetic findings in two synchronous secondary peripheral chondrosarcomas in a patient with multiple osteochondromas
| Autor: | Nikos Pandis, Sverre Heim, Efthimios Dimitriadis, Petter Brandal, Niki Arnogiannaki, Anastasios I. Kyriazoglou |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Osteochondroma Cancer Research Pathology medicine.medical_specialty Multiple osteochondroma DNA Mutational Analysis Karyotype Chondrosarcoma Biology N-Acetylglucosaminyltransferases Malignant transformation Skeletal disorder Genetics Enchondroma medicine Humans Molecular Biology Chromosome Aberrations Comparative Genomic Hybridization Secondary Peripheral Chondrosarcoma Anatomy Middle Aged medicine.disease Chromosome Banding Cell Transformation Neoplastic Exostoses Multiple Hereditary Comparative genomic hybridization |
| Zdroj: | Cancer Genetics. 204:677-681 |
| ISSN: | 2210-7762 |
| DOI: | 10.1016/j.cancergen.2011.10.013 |
| Popis: | Secondary peripheral chondrosarcoma is a malignant chondroid tumor arising in a benign precursor, either an osteochondroma or an enchondroma. Multiple osteochondromas syndrome (MO) is an autosomal dominant skeletal disorder associated with bony growths in the form of osteochondromas that occasionally undergo malignant transformation to secondary peripheral chondrosarcomas. We describe the genetic examination of three secondary peripheral chondrosarcomas that had arisen synchronously from osteochondromas in a patient with MO by chromosome banding, high resolution chromosomal comparative genomic hybridization, and mutation analysis of the EXT1 and EXT2 genes. In two of the tumors (the third was not genetically informative), very similar chromosome abnormalities were found, indicating that they must somehow be part of the same neoplastic process in spite of being anatomically distinct. |
| Databáze: | OpenAIRE |
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