The distribution of urate in human and primate kidney
| Autor: | P. S. Symchych, Felix E. Demartini, P. J. Cannon |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Kidney
medicine.medical_specialty urogenital system Reabsorption Renal cortex Countercurrent multiplication Vasa recta Haplorhini Biology General Biochemistry Genetics and Molecular Biology Uric Acid chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Renal pathology Internal medicine medicine Renal medulla Methods Uric acid Animals Humans |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 129(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryTransverse sections of human kidney were obtained at autopsy, frozen, and subsequently analyzed for uric acid. In 15 of 18 kidneys, 14 of which were free of renal pathology, tissue urate concentrations increased progressively from the renal cortex to papillary tip. Similarly in 5 antidiuretic rhesus monkeys infused with a sodium urate solution, increasing corticomedullary urate gradients were found in frozen kidney slices. In hydrated monkeys similar infusions were not associated with the occurrence of a urate gradient. The data indicate that urate may undergo stratification in human and antidiuretic primate kidney with higher concentrations occurring in the renal medulla. Although the lack of microscopic evidence does not exclude urate microcrystallization in medullary interstitial tissue, the possibilities that urate may undergo either countercurrent multiplication as a consequence of reabsorption beyond proximal tubules or countercurrent exchange by the vasa recta after passive reabsorption in t... |
| Databáze: | OpenAIRE |
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