Gelatin-stabilized composites of silver nanoparticles and curcumin: characterization, antibacterial and antioxidant study
| Autor: | Nguyen Thi Thu Hoai, Nguyen Thanh Truc, Nguyen Thi Hiep, Nguyen Tan Dat, Vo Van Toi, Tran Thi Thanh Loan, Tran Ngoc Quyen, Nguyen Thi Phuong Nghi, Ly Loan Khanh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
30 Bio-inspired and biomedical materials
Antioxidant food.ingredient antioxidant medicine.medical_treatment lcsh:Biotechnology 02 engineering and technology curcumin (Cur) 010402 general chemistry 01 natural sciences Gelatin Silver nanoparticle wound treatment chemistry.chemical_compound food Gelatin gel lcsh:TP248.13-248.65 medicine lcsh:TA401-492 gelatin (Gel) 503 TEM STEM SEM General Materials Science Wound treatment 103 Composites Therapeutic agents 211 Scaffold / Tissue engineering / Drug delivery silver nanoparticles (AgNPs) 021001 nanoscience & nanotechnology 0104 chemical sciences antibacterial chemistry Curcumin Bio-inspired and Biomedical Materials lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology Nuclear chemistry |
| Zdroj: | Science and Technology of Advanced Materials Science and Technology of Advanced Materials, Vol 20, Iss 1, Pp 276-290 (2019) |
| ISSN: | 1878-5514 1468-6996 |
| Popis: | This is a preliminary study of a material comprising gelatin (Gel), silver nanoparticles (AgNPs) and curcumin (Cur) aimed for wound-healing treatment. Gelatin was used to stabilize AgNPs and encapsulate curcumin to form a therapeutic composite (GelCurAg) for their strong bactericidal and antioxidant properties. GelCurAg formulations with different gelatin concentrations were characterized to attain information about their physiochemical properties and the loading efficiency of therapeutic agents. In vitro assessment of GelCurAg focused on antibacterial, antioxidant and cytotoxic aspects. The results suggested that Gel1CurAg (synthesized from 1% gelatin solution) could be utilized as potential therapeutic agents in treating infectious wound owing to its bactericidal and antioxidant effects and low toxicity for clinical uses. GRAPHICAL ABSTRACT |
| Databáze: | OpenAIRE |
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